ECT Article

ECT Article

By Asif Malik, MD

This narrative is not a scientific treatise but an attempt to answer the common questions that arise when patients are referred to ECT. This can also help providers decide when to refer to a patient for ECT.

Electro-convulsive therapy, or ECT is sometimes commonly referred to as “Shock therapy”. Despite the negative depiction in the cinema, this treatment has been used in the current form since the 1960s with a slow evolution greatly decreasing the incident of side effects and improving patient outcomes.

When does ECT work best:

Acute episodes of psychosis, mania or depression.
When depression is accompanied by a biological shift with disturbance in sleep and appetite
Catatonia (Preferred treatment)
Neuroleptic malignant syndrome

When does it work quite well:

Acute exacerbation of a chronic psychotic illness. Patients will improve functionally but may not enter remission
Severe obsessive compulsive disorder

When its better to avoid:

Personality disorders, unless the above mentioned conditions are present and are independent of the personality pathology
Primary anxiety disorders
Primary diagnosis of PTSD unless above conditions are present
Evolving brain injury

Special situations:

There are no absolute contraindications of ECT. Relative contraindications include recent myocardial infection (heart attack) or GI bleed (blood in stools or dark stools). Medical clearance is generally done by the patient’s primary provider or the internist treating the patient on the medical unit. Generally, ECT is considered to be a very safe and life saving treatment which has been used in patients with brain implants (Deep brain stimulator electrodes) , cardiac transplant patients, as well as women in various stages of pregnancy.

Should I get ECT/ Should I refer my patient for ECT?

This is a list of common reasons for recommending ECT.

1. Treatment failure

Treatment failure is the most common reason for recommendation of ECT. ECT has been shown to be effective in 60-80% of patients who have failed conventional treatments. With careful selection of patients, response and remission rates are very high in patients who have failed prior treatments. Conventional treatments include pharmacological interventions with medications including anti-depressants of the SSRI (Fluoxetine, sertraline, paroxetine etc) and non-SSRI (Bupropion, mirtazapine , duloxetine and some more) classes. Many patients are also tried with antipsychotic medications (olanzapine, quetiapine, aripiprazole) , mood stabilizers such as (valproic acid and lithium).

As a generally accepted standard, the anti-depressant medications need to be used for several weeks at a therapeutic dose prior to a switch and calling it a treatment failure unless the patient is not able to tolerate the intervention. Antipsychotic medication augmentation as well as introduction of mood stabilizers are also used in the later stages of treatment if mono-therapy is not effective.

2. Severity of illness

Another factor in considering treatment with ECT is the severity of illness. It is not uncommon to treat patients with ECT early on in their illness or using it as a first line treatment if they are severely ill at the time of presentation. Weight loss, imminent suicide risk, failure to thrive, inability or refusal to eat and a severe ongoing medical illness which makes waiting non-feasible are all indicators that ECT would be a helpful treatment modality.

3. Depression and affective disorders

Severe major depressive episode, and mood episodes with predominant depressive pathology are some of the common reasons behind referrals. Generally, if depressive symptoms are accompanied by a “biological shift” indicated by cachexia and weight loss and insomnia or hypersomnia, patients will tend to respond well to the treatment.

4. Catatonia

Catatonic patients tend to respond well to ECT treatments. Care needs to be exercised to rule out behavioral difficulties, somatoform and factitious illnesses.

5. Acute mania

Acute mania tends to respond well to ECT and the time to remission might be reduced in many instances. There are times when prolonged hospitalizations and treatment trials could be avoided by utilizing ECT as a first line treatment option.

6. Acute psychosis

Acute psychosis can respond quite rapidly to Electro-convulsive therapy.

Common questions;

1: Will it erase my memory?

No. ECT causes short term memory impairment. Common causes of longer term memory impairments are delirium, cognitive decline related to dementia or age and pseudo-dementia from the incomplete remission of the underlying condition.

You can expect the memory to be quite poor starting the middle of the series till the end. You may not recall conversations with your family and your health care providers completely.

2: Will I get pain killers for my headache?

Generally not but every patient situation is determined by the treating provider.

3: Will I be “hooked” ? Will I continue needing the treatments?

Maintenance treatments every 4-6 weeks or so are sometimes recommended if you have a relapse which does not improve with medications. Generally, this is voluntary.

4: Do I need to stay in the hospital?

If you are otherwise healthy and stable (no medical or psychiatric indications for hospitalization), you can stay at home. You will not be allowed to drive back home, and should arrange for this accordingly.

5: How many treatments do I need?

Generally, eight treatments are considered a series. Treatments are generally done every other day, no more than three a week. Multiple treatments in one day are no longer done as they are no more effective. While eight treatments are an initial goal, some patients show improvement in as few as 3-4 treatments and some patients need more than 15. Each patient’s goal is determined individually.

6: I do not want ECT. Can you force me to get one?

No. Generally, this is a voluntary treatment. In some situations where the patient is not considered “capacitated” or lacks the decision making capacity due to psychiatric or medical impairment, courts can order ECT. This is done is two psychiatrists concur that this is the best course of action and the family and loved ones are on board.

7: Is it painful?

No. Muscle soreness and headaches are sometimes reported post ECT and are treated with over-the counter anti inflammatory medications. Opiate pain medications are rare required. Patients prone to headaches can be pre-treated with anti-inflammatory medications and this helps quite a bit.

8: Does it work/How does it work?

Yes, it works rather effectively. Electricity in ECT induces seizures. The brain’s seizure -stopping mechanism then kicks in and releases neurotropic factors which stop the seizure and provide improvement in psychiatric condition. The exact mechanism of ECT’s action is not known.

9: How long is the seizure/What is it does not stop?

Seizures range from a few seconds to two minutes and longer. Conventional wisdom suggests seizures should be longer than 30 seconds to be effective. There are other variables now which are considered for predicting the effectiveness of the treatment.
If the seizure does not stop between 90-120 seconds, the anesthetist might inject a seizure stopping medication which works quite quickly.

10: Can I drive/return to work tomorrow?

Depending on the total number of treatments, your overall health and cognitive state, you might need 2-5 days prior to being able to drive. If you have early dementia, your doctor might advise you to not drive for longer.

Returning to your job would depend on your age, overall level of functioning prior to the treatments and number of treatments. Many people are able to work in-between the maintenance treatments.

11: Will I get one sided or two sided treatment?

Unilateral and bilateral refers to electrode placement. While unilateral electrode placement causes less memory difficulties, a higher setting is required to induce seizures. Given that the treatments are generally for a brief amount of time, bilateral treatments are preferred by many psychiatrists given the higher effectiveness.